Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicine

Rating:
Summary: Thalidomide Reborn
Review: Anyone who could pay attention to newspapers in the 1960s remembers the stories of thalidomide. Thousands of women took this super-safe sedative, or morning sickness suppressant, and found that their children were born with grotesquely stunted limbs like flippers, or perhaps no arms or legs at all. The dismal story of how thalidomide was invented, marketed, and withdrawn is a big part of the fascinating account in _Dark Remedy: The Impact of Thalidomide and its Revival as a Vital Medicine_ (Perseus Publishing), by Trent Stephens and Rock Brynner, but as the title implies, the story is not all gloom. The initial part of the story is simply shocking, with the German drug manufacturer displaying incompetence and selfishness throughout the product's development, testing, and distribution. When problems emerged, the company did a cover up, hired a detective to keep tabs on the doctors and patients who were complaining, and kept selling the drug.

The United States was a huge potential market for thalidomide. A subsidy of Vick Chemical Company (makers of Vicks VapoRub) was set to release it in the US in 1961. The company was sure it would get quick approval from the Food and Drug Administration, because at the time there was no requirement to show that the drug worked, it was up to the FDA to find any data to show any dangers, and pharmaceutical representatives did favors for FDA officials. The FDA, and the company, did not reckon on young FDA staffer Dr. Frances Kelsey, who was appalled by the sloppiness of the application. The story of the drug company's recklessness is shocking, but Dr. Kelsey's refusal to bow to heavy pressure, from both the company and her superiors in the FDA, is one of the inspiring parts of the book. She got a civilian service medal from President Kennedy, and it was due to her unflagging refusal to compromise that thalidomide didn't make it to American shelves.

Dismaying and astonishing are the stories of how the drug got approved elsewhere, and how the makers attempted to absolve themselves of any financial responsibility to the victims. But those are only part of the thalidomide story. The other part is that thalidomide is back. Results published in 1965 showed that thalidomide has an enormous capacity to relieve the pain of leprosy. This is important for lepers, of course, but there is not a huge population of lepers these days. More recently and more importantly, thalidomide has been used for HIV; it was found that it was good for the wasting of the illness and the mouth ulcers. From these results have grown the research that shows that thalidomide can be useful for victims of cancer (especially multiple myeloma) and autoimmune diseases such as lupus.

Current research on the drug (and author Stephens has done some of it) has pursued just how thalidomide caused its extraordinary birth defects, so that the drug company now making it could work on an analogue drug that has all the good effects and none of the birth deformities. In fact, such a drug is undergoing trials. Thalidomide, this excellent history and scientific explanation shows, has ruined lives, but it has also caused needed changes in drug approval processes, and still has potential for diminishing suffering.

Rating:
Summary: A profound and moving tale
Review: As outlined above, this book details the history of thalidomide, including its discovery, introduction into society, harmful effects, withdrawal, and eventual rebirth as a useful medication. It is very interesting and keeps your attention throughout the entire book. I am a physician and learned very much from this book, including some information about the FDA, and even about what thalidomide is used for today. I would say that you should read this book if you have any interest in medical history told in a narrative fashion. It will educate you on a tragic event in history and the amazing effects of medications upon human beings. Great, great, great book!

Rating:
Summary: How thalidomide caused the greatest medical disaster
Review: Dark Remedy tells of how thalidomide caused the greatest medical disaster in history - but today is enjoying a comeback as a life-saving treatment despite its side effects. Dark Remedy considers how the drug became a nightmare in the 1960s, how it was banned, and how it's receiving new research attention today which may reinstate its use without its side effects. An intriguing medical history.

Rating:
Summary: A Compelling Read for Layperson and Scientist Alike
Review: This short book is a compelling drama, complete with innocent victims, dark villians and compassionate and dedicated heros. But it is no simple account in black and white. Rather it is a textured retelling of the profound human tragedy of Tahlidomide, it's impact on the phamaceutical industry, the FDA's regulatory role, and the pursuit of scientific insight.

It will come as a surprise to many laypeople that Thalidomide, notorious for the extreme birth defects it caused when it burst upon the consciousness of the world in the early 1960s, is now used for the treatment of dozens of conditions. This book details the painful story of Thalidomide's devastation; the greed and indifference of it's corporate promoters; the dilligence and dedication of a handful of doctors who helped curtail it's spread, the tortured legal struggle of it's victims, and the difficult and collaborative process by which scientists discovered it's secrets and are putting it to use to relieve suffering.

The history is recounted on a human scale, making the drama real to the reader. The science, as complex as it is - including molecular structures and the mechanisms of DNA - is articulated in a way that makes it accessible even to the layperson.

I highly recommend it.

Rating:
Summary: A Compelling Read for Layperson and Scientist Alike
Review: This short book is a compelling drama, complete with innocent victims, dark villians and compassionate and dedicated heros. But it is no simple account in black and white. Rather it is a textured retelling of the profound human tragedy of Tahlidomide, it's impact on the phamaceutical industry, the FDA's regulatory role, and the pursuit of scientific insight.

It will come as a surprise to many laypeople that Thalidomide, notorious for the extreme birth defects it caused when it burst upon the consciousness of the world in the early 1960s, is now used for the treatment of dozens of conditions. This book details the painful story of Thalidomide's devastation; the greed and indifference of it's corporate promoters; the dilligence and dedication of a handful of doctors who helped curtail it's spread, the tortured legal struggle of it's victims, and the difficult and collaborative process by which scientists discovered it's secrets and are putting it to use to relieve suffering.

The history is recounted on a human scale, making the drama real to the reader. The science, as complex as it is - including molecular structures and the mechanisms of DNA - is articulated in a way that makes it accessible even to the layperson.

I highly recommend it.