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Rating: 
Summary: Tear's of a Cheetah
Review: Better to have been titled, "The Memoirs of a Civil Servant", this book is bloated with a self congratualatory stain that you just can't get off the page. O'Brien conducted the globtrotting refered to in this book on the $$$$$ of the National Cancer Institute. So where is the cure for cancer ? Certainly not slipped in among the pages about the chetah's and the pandas. Science is a very expensive business and this book simply portrays an ego in pursuit of a special interest and personal fame; a theif in the night who occassionally throws the readers a few crumbs of connection to imply relevance to the larger picture real medical science. Shameful. You can truly serve any evolutionary or genetics curiosity by reading and enjoying the great but humble works of Stephen J. Gould
Rating: 
Summary: Fascinating!
Review: I enjoyed the book very much.I would recommend it highly for anyone who has an interest in understanding basic genetics or for someone who is just interested in learning something new. Dr. O'Brien is a wonderful story teller and writes in a language that is easily understandable. He slowly introduces the concepts in an interesting progressive manner which enables the reader to understand the more advanced concepts toward the end of the book. I thought the book was truly fascinating.
Rating:
Summary: Fascinating!
Review: It has been but a few decades since the structure of the DNA molecule was discovered, a structure of astonishing simplicity. The complexity comes with the infinite arrangements of the four simple letters of the molecule, and the array of proteins that the arrangements code for. We are just at the beginning of understanding and using the coding, and Stephen O'Brien, head of the Laboratory of Genomic Diversity at the National Cancer Institutes, is one of the decoders. In _Tears of the Cheetah: And Other Tales from the Genomic Frontier_, he has told fourteen stories of deciphering DNA for the purpose of determining animal history. There are remarkable discoveries outlined here, in which O'Brien directly took part or supervised those who did (he is gracious in his acknowledgement of these colleagues), and some of the molecular science is complex and will challenge readers who are not familiar with the field. The stories themselves, however, are compelling, and will be a good introduction to just what sort of mysteries are being unlocked by our knowledge of DNA and genomes (the sum total of an animal's genes), and how the solution of the mysteries holds potential not just for intellectual satisfaction but for the benefit of humanity.The story that gives the book its title is about genetic studies of wild cheetahs, and it reflects a theme of a population bottleneck which is frequent in these pages. Because 12,000 years ago, the number of cheetahs were drastically cut (probably by an epidemic), only a handful remained to breed. When O'Brien came to investigate why cheetahs were breeding so badly in zoos and preserves, there was a shock: there was almost no variation in cheetah DNA. They were as inbred as lab mice. Some mice in China a thousand years ago, however, had been squeak by a viral plague because they had part of the virus incorporated into their own DNA; this may mean that all sorts of DNA strands of viral preventatives are awaiting our discovery, and use. There is a chapter here on Florida's endangered panthers, which like cheetahs are dangerously inbred, and the politics of conservation of species and subspecies. O'Brien explains how feline immunodeficiency virus (something like our HIV) infects many cat species but kills few of them because beneficial genetic changes are evolving. There is a fine chapter on the century of controversy about how to classify panda bears. There were good arguments from the physical characteristics of pandas that put them in the bear family, but there were others that indicated they were related more to raccoons. The argument was at a dead end; some of the means of classifying animals are based on simple human judgement and are therefore to a degree subjective. With examination of the DNA, however, O'Brien's team could show that the panda's ancestors split away from the family of bears about twenty million years ago. Pandas are bears, and the controversy is, thanks to molecular genetics, over. Looking at DNA has been the way to show that meat from endangered whales was being sold illegally in Japanese markets, forever changing the sham arguments that the Japanese used that their whaling was only for scientific research. O'Brien's team was involved in solving a murder by DNA fingerprinting, but not DNA of the murderer; O'Brien is an expert on feline DNA, and they had to make a link between the murderer and the only applicable physical evidence, cat fur on a jacket spattered by the victim's blood. The cat belonged to the murderer's family. Another chapter shows that amazingly, the human gene lines that squeaked through the bubonic plague in the Middle Ages may be the ones that are best fighting off AIDS. As both a memoir along the lines of "My Most Unforgettable Genomic Researches" and an introduction to what is going to be an increasingly important method of understanding our world's biology, _Tears of the Cheetah_ is a real success. The really tantalizing prospect, however, the main message of the book, is that humans and animals may have a genetic store of disease-fighting capacity that is only beginning to be understood, and has tremendous potential for improving health worldwide.
Rating:
Summary: Animal Genes and Lessons for Humans
Review: It has been but a few decades since the structure of the DNA molecule was discovered, a structure of astonishing simplicity. The complexity comes with the infinite arrangements of the four simple letters of the molecule, and the array of proteins that the arrangements code for. We are just at the beginning of understanding and using the coding, and Stephen O'Brien, head of the Laboratory of Genomic Diversity at the National Cancer Institutes, is one of the decoders. In _Tears of the Cheetah: And Other Tales from the Genomic Frontier_, he has told fourteen stories of deciphering DNA for the purpose of determining animal history. There are remarkable discoveries outlined here, in which O'Brien directly took part or supervised those who did (he is gracious in his acknowledgement of these colleagues), and some of the molecular science is complex and will challenge readers who are not familiar with the field. The stories themselves, however, are compelling, and will be a good introduction to just what sort of mysteries are being unlocked by our knowledge of DNA and genomes (the sum total of an animal's genes), and how the solution of the mysteries holds potential not just for intellectual satisfaction but for the benefit of humanity. The story that gives the book its title is about genetic studies of wild cheetahs, and it reflects a theme of a population bottleneck which is frequent in these pages. Because 12,000 years ago, the number of cheetahs were drastically cut (probably by an epidemic), only a handful remained to breed. When O'Brien came to investigate why cheetahs were breeding so badly in zoos and preserves, there was a shock: there was almost no variation in cheetah DNA. They were as inbred as lab mice. Some mice in China a thousand years ago, however, had been squeak by a viral plague because they had part of the virus incorporated into their own DNA; this may mean that all sorts of DNA strands of viral preventatives are awaiting our discovery, and use. There is a chapter here on Florida's endangered panthers, which like cheetahs are dangerously inbred, and the politics of conservation of species and subspecies. O'Brien explains how feline immunodeficiency virus (something like our HIV) infects many cat species but kills few of them because beneficial genetic changes are evolving. There is a fine chapter on the century of controversy about how to classify panda bears. There were good arguments from the physical characteristics of pandas that put them in the bear family, but there were others that indicated they were related more to raccoons. The argument was at a dead end; some of the means of classifying animals are based on simple human judgement and are therefore to a degree subjective. With examination of the DNA, however, O'Brien's team could show that the panda's ancestors split away from the family of bears about twenty million years ago. Pandas are bears, and the controversy is, thanks to molecular genetics, over. Looking at DNA has been the way to show that meat from endangered whales was being sold illegally in Japanese markets, forever changing the sham arguments that the Japanese used that their whaling was only for scientific research. O'Brien's team was involved in solving a murder by DNA fingerprinting, but not DNA of the murderer; O'Brien is an expert on feline DNA, and they had to make a link between the murderer and the only applicable physical evidence, cat fur on a jacket spattered by the victim's blood. The cat belonged to the murderer's family. Another chapter shows that amazingly, the human gene lines that squeaked through the bubonic plague in the Middle Ages may be the ones that are best fighting off AIDS. As both a memoir along the lines of "My Most Unforgettable Genomic Researches" and an introduction to what is going to be an increasingly important method of understanding our world's biology, _Tears of the Cheetah_ is a real success. The really tantalizing prospect, however, the main message of the book, is that humans and animals may have a genetic store of disease-fighting capacity that is only beginning to be understood, and has tremendous potential for improving health worldwide.
Rating: 
Summary: I like this book a lot
Review: It's nicely written, contains interesting genetic facts about the animal kingdom I never would've known.(cheetahs were so badly inbred plus the genetic distance of african lions to asian lions).
Rating:
Summary: Stories combining wildlife, genetics and emerging diseases
Review: The bits of the book I have read so far have been interesting and fun to read. I think the reader from Seattle with the poor spelling skills who believes that wildlife conservation is a "special interest" should quit griping in his anonymous envy of O'Brien, who has produced hundreds of scientific papers furthering our understanding of human diseases, in many cases by studying related diseases in wildlife. Many of the stories are highly interesting. Read the book.
Rating:
Summary: Stories combining wildlife, genetics and emerging diseases
Review: The bits of the book I have read so far have been interesting and fun to read. I think the reader from Seattle with the poor spelling skills who believes that wildlife conservation is a "special interest" should quit griping in his anonymous envy of O'Brien, who has produced hundreds of scientific papers furthering our understanding of human diseases, in many cases by studying related diseases in wildlife. Many of the stories are highly interesting. Read the book.
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