Group Sequential Methods with Applications to Clinical Trials

Rating:
Summary: clear coverage for practicing biostatisticians
Review: Advances in the theory of repeated significance testing in the 1980s and 1990s has made sequential methods practical by identifying stopping rules for data collected sequentially but in groups. This material is now used to plan interim analyses and both safety and efficacy group sequential trials for clinical trials. This text provides for the first time thorough coverage of these advances with suitable references to the literature.

It should be on the bookshelf of any biostatistician who conducts clinical trials for pharmaceutical or medical device companies.