Rating: 
Summary: Marvelous Text
Review: "...a marvelous text...plenty of definitions and excellent illustrations essential for an introductory textbook...the reader is...guided wonderfully through the text...this text is an essential cornerstone of information..." (Pharmaceutical Research, Vol. 19, No. 12, December 2002)
Rating:
Summary: User Friendly
Review: "...a second edition to incorporate new developments in genome science and to make the book more 'user friendly'...the book substantially exceeds that modest objective; this is a text suitable for anyone who does not specialize in genome science." (Clinical Chemistry, Vol. 48, No. 12)
Rating:
Summary: Useful Text
Review: "...probably the most up-to-date textbook on molecular biology...a useful text...and reference..." (Annals of Pharmacotherapy, September 2003)
Rating:
Summary: Masterpiece
Review: "...this didactic masterpiece...model of a modern university textbook deserves to be read and studied by...students worldwide." (Modern Pathology, Vol. 15, No. 9, 2002)
Rating:
Summary: Review in Heredity (vol 83, Sept 99)
Review: "This is a superb textbook for modern molecular biology. The set-up of the book is very reader-friendly. Everything is cross-referenced, which is enormously helpful. Another nice aspect of the book is the small, digestible sections separate from the main body of text. Overall Brown's book is an excellent textbook that provides a thorough account of what is known about Genomes today."
Rating:
Summary: Review in Heredity (vol 83, Sept 99)
Review: "This is a superb textbook for modern molecular biology. The set-up of the book is very reader-friendly. Everything is cross-referenced, which is enormously helpful. Another nice aspect of the book is the small, digestible sections separate from the main body of text. Overall Brown's book is an excellent textbook that provides a thorough account of what is known about Genomes today."
Rating:
Summary: Excellent book
Review: An excellent book. Incredible pictures. Starts from a basic enough point for most computer scientists, it even covers many
"exceptions" to many of the rules discovered in nature. Even covers microarrays.
Rating: 
Summary: Good overview of modern genetics
Review: Because of the explosion of genetics research and technology in today's world, many textbooks and monographs on the subject have appeared. This book is certainly one of the finest of these, and emphasizes, as stated in the the preface, the major research issues in genetics, rather than issues that were important two decades ago. Genomes, not genes, the author states, should be the topic of primary focus. The more fundamental 'microscopic' processes such as DNA replication and mutation are studied in terms of their effects on the genome. This reflects the current move in genetics to find common ground between classical genetics and modern molecular genetics. Clearly the author is very excited about the developments in genetics that have taken place in the last decade, and this shows in his writing. The only major omission in the book is the lack of exercises; these are of upmost importance in the learning process. The book, written for beginning graduate students, could also be useful to mathematicians, physicists, or computer scientists who are moving into bioinformatics or computational biology. Some of the more interesting discussions in the book include: 1. The C-value paradox: The correlation between the complexity of an organism and the size of its genome is explained by a space optimization argument, i.e. the genomes of simpler organisms conserve space by packing the genes closer together. 2. Using DNA markers versus gene markers for genetic mapping. 3. Single nucleotide polymorphisms, oligonucleotide hybridization analysis, and their use in DNA chip technology and dynamic allele-specific hybridization. 4. The need for physical mapping techniques and the discussion on the discrepancies between genetic and physical maps of S. cerevisiae chromosome III. 5. The use of orthogonal field alternation gel electrophoresis to separate molecules of more than 50kb in length. 6. Rapid sequence acquisition strategies, such as expressed sequence tags and sequence skimming. 7. The ethicial ramifications of the Human Genome Project. 8. The difficulty of existing software programs to assist in the location of exon-intron boundaries. 9. Homology searching and analysis. 10. The telomere and the role of telomeric proteins in capping chromosome ends. 11. The location of genes and the isochore model of genome organization. 12. The role of extra chromosomal genes in explaining inheritance patterns of some phenotypes in fungi, yeasts, and algae. 13. The (unanswered) questions as to why organelle genomes cannot be transported through the membranes that surround mitochondira and chloroplasts. 14. The discovery in the 1980s that DNA transfer from organelle to nucleus still occurs and the role of promiscuous DNA. 15. The experimental evidence that genes are made of DNA. 16. The role of bacterial RNA polymerase as a 'sliding clamp'. 17. The three-dimensional structure of tRNA. 18. Ribosome frameshifting. 19. Transient changes in genome activity. 20. Rearrangements of genomes 21. Genome regulation by feedback loops. 22. The genetic basis of flower development. 23. Mutations and recombination. Readers interested in genetic algorithms will appreciate this discussion. 24. The experimental detection of mutations. 25. Adapative mutations in E. coli. Because of its challenge to the current paradigm of evolution, this discussion was particularly interesting. 26. Evidence for ancient genome duplication and molecular phylogenetics.
Rating:
Summary: Cell Biology in terms of Genomes
Review: Cell biology is described very well in terms of Genomics language. So it is certainly an excellent book to learn cell biology and to understand the genomes. Each chapter is well written and covered with important references. Summary of chapter at its end would be helpful to quick review about the chapter. Hope author adds this in the next version.
Rating:
Summary: Cell Biology in terms of Genomes
Review: Cell biology is described very well in terms of Genomics language. So it is certainly an excellent book to learn cell biology and to understand the genomes. Each chapter is well written and covered with important references. Summary of chapter at its end would be helpful to quick review about the chapter. Hope author adds this in the next version.
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