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Without Miracles: Universal Selection Theory and the Second Darwinian Revolution

Without Miracles: Universal Selection Theory and the Second Darwinian Revolution

List Price: $32.00
Your Price: $32.00
Product Info Reviews

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Rating: 5 stars
Summary: FULL? VERISON ONLINE
Review: That applies to this book, as well as the concepts described herein.

When a book can alter your perception and understanding of the world for the better you reread it. I'm currently on my third formal reading of this masterpiece. I go back to it often.

Cziko has brought to life the simple but powerful concept that Campbell called evolutionary epistemology: blind variation and selection. I use these concepts in everyday life (risk-taking, creativity, trade-off decision-making). Even if not useful, the concept would enegender admiration for its sheer beauty. The fact that it can be useful and fun is an added benefit.

Rating: 5 stars
Summary: Deceptively simple process generates beauty!
Review: That applies to this book, as well as the concepts described herein.

When a book can alter your perception and understanding of the world for the better you reread it. I'm currently on my third formal reading of this masterpiece. I go back to it often.

Cziko has brought to life the simple but powerful concept that Campbell called evolutionary epistemology: blind variation and selection. I use these concepts in everyday life (risk-taking, creativity, trade-off decision-making). Even if not useful, the concept would enegender admiration for its sheer beauty. The fact that it can be useful and fun is an added benefit.

Rating: 5 stars
Summary: FULL? VERISON ONLINE
Review: This book can be found at http://faculty.ed.uiuc.edu/g-cziko/wm/

Rating: 4 stars
Summary: A Must! But far from flawless...
Review: This book is surely a must for anyone interested in phylosophical discussions concerning "darwinian" (or better, neo-darwinian) evolution theory, and its potential to explain other fields where any kind of innovation is created. The author describes these innovations as "puzzles of fit" of an organism or of a system to another organism or system, and he brilliantly equals all these "fits" to "knowledge". Cziko reached a good level of quality in his transdisciplinary approach, putting together data from fields like evolutionary biology, immunology, neurobiology, animal and human learning, human thought and language, scientific knowledge growth, and cultural adaptation. For this, he no doubt deserves a four-star ranking. But then, there come the flaws...

The central issue in the book is that just any kind of innovation, puzzle of fit, knowledge growth, or whatever you call it, can only be achieved through a process very much like biological evolution as accepted by the neo-darwinian paradigm: cumulative blind variation followed by the survival of the fittest. Cziko also shows how explanations for these puzzles of fit have evolved in all fields from providential explanations (like in the book of Genesis, where things happened to achieve a pourpose previously devised), through instructionist ones (like Lamarck's "Use and Disuse" plus "Inheritance of Acquired Characters", where the environment would "force" the individual creatures to change just in the right, successful way, and then the creatures would pass these changes on to their offsprings), and finally to selectionist ones (Darwin's Selection Theory). He says that only selectionist explanations can give truly "scientific" and "naturalistic" accounts for these fits, without recoursing to miraculous schemes. In short: Cziko brings us the good news that not only are we merely machines (like we have feared ever since the mechanical physics of Newton), but we are blind ones too!

The starting point of his reasoning is evolutionary biology, and Cziko's understanding of it seems to me too narrow-minded, with a strong bias toward the old notions of New-Darwinism. Consequently, his report and deductions on it are misinformative. Evolution was (and, to a large extent, still is) thought to be based on "variation and survival of the fittest". But in the past the view of the causes of these variations were believed to be basically errors: DNA damage by the environment, and failure of the organism to correct damages or to make precise copies of the DNA. It's been a long time now that this view has changed dramatically, and organisms, even as simple as bacteria, are now known (from before 1990) to possess amazing control over the ways and the contexts in which these variations happen. They can trigger DNA mutation under appropriate conditions (stress, threats to survival), and even control which areas of the genome will be subject to change. This renders organisms much more "smartly" interactive with the environment as might be expected from reading Cziko.

So, what Cziko did not tell about the process of antibody creation by B-Lynphocytes is that when they undergo somatic hypermutation to fine tune their antibody production to the antigen, this hypermutation is, first, triggered by the interaction with the very antigen, and second, it is far from blind: the mutation happens only in a very restricted area of the chromosome, changing only the areas of the antibody molecule that interact with the antigen (and not even the whole molecule!). So this is a very "thematic" kind of mutation-variation; maybe "short-sighted", but surely not "blind"!

When he comments on the phenomenon of "directed mutation", the strange capability of many procarionts (like bacteria) to seemingly direct their mutation to the desired result, he takes a rather cynical and slightly arrogant stand, apparently rejecting the existance of the phenomenon itself, even saying "But let us continue to imagine for a moment that a bacterium was able to change just those genes regulating metabolism in just the right way to allow for the digestion of a foreign sugar". It seems that he read only two research articles on this, and not quite well, and draw much of his attitude towards the phenomenon from his academic-environment prejudiced and uninformed criticism. By the time he was writing his book , directed mutation had been fully demonstrated by many researchers, and not only by Cairns. Actually, even as early as 1984, four years before Cairns revolutionary and controversial paper on it, J.A. Shapiro had already shown the phenomenon fully (Observations on the Formation of Clones Containing araB-lacZ cistrons fusions. Molecular & General Genetics 1984;194(1-2):79-80), only in a much more discreet maner. By 1995, a wealth of information was already available, from researchers like Shapiro and B.G. Hall, among others, and now even eukariotes (yeast) are known to perform "directed mutation" (Hall BG. Adaptive Mutagenesis: a Process that Generates Almost Exclusively Beneficial Mutations. Genetica 1998;102(103):109-125.). Strikingly, this process shows some resemblance to human B-lynphocyte somatic hypermutation!

When Cziko moves on to the other areas, scientific knowledge growth, etc, the already "short-sighted" (and not blind) variation seems to have undergone a surgical operation on its eye and starts to see almost sharply. Also, the second step, that is, the survival of the fittest (in biology, through killing the non-fit) seems to change to a true "selection" process (choosing one among many, by identifying its desirable qualities, which is quite different from "survival of the fittest"). Even Campbell and Pinker, which he defines as fully (or almost) selectionists, seem to turn to rather providential viewpoints, like "innativism" and "constraints", for triggering and orienting the variation, and guiding the selection, not succeding in solving Meno's providential dilema: "...if you don't already possess the knowledge you are looking for, how will you know when you have found it?"

Cziko, like many, wrongly equals "scientific" and "naturalistic" explanations to "mechanical" ones, and since our mechanistic view of nature is basically deterministic, he only sees lamarckism as an instructionist process, not a "freely-willed" one, failing to address vital phenomena like human consciouness and apparent free-will.

Rating: 4 stars
Summary: A Must! But far from flawless...
Review: This book is surely a must for anyone interested in phylosophical discussions concerning "darwinian" (or better, neo-darwinian) evolution theory, and its potential to explain other fields where any kind of innovation is created. The author describes these innovations as "puzzles of fit" of an organism or of a system to another organism or system, and he brilliantly equals all these "fits" to "knowledge". Cziko reached a good level of quality in his transdisciplinary approach, putting together data from fields like evolutionary biology, immunology, neurobiology, animal and human learning, human thought and language, scientific knowledge growth, and cultural adaptation. For this, he no doubt deserves a four-star ranking. But then, there come the flaws...

The central issue in the book is that just any kind of innovation, puzzle of fit, knowledge growth, or whatever you call it, can only be achieved through a process very much like biological evolution as accepted by the neo-darwinian paradigm: cumulative blind variation followed by the survival of the fittest. Cziko also shows how explanations for these puzzles of fit have evolved in all fields from providential explanations (like in the book of Genesis, where things happened to achieve a pourpose previously devised), through instructionist ones (like Lamarck's "Use and Disuse" plus "Inheritance of Acquired Characters", where the environment would "force" the individual creatures to change just in the right, successful way, and then the creatures would pass these changes on to their offsprings), and finally to selectionist ones (Darwin's Selection Theory). He says that only selectionist explanations can give truly "scientific" and "naturalistic" accounts for these fits, without recoursing to miraculous schemes. In short: Cziko brings us the good news that not only are we merely machines (like we have feared ever since the mechanical physics of Newton), but we are blind ones too!

The starting point of his reasoning is evolutionary biology, and Cziko's understanding of it seems to me too narrow-minded, with a strong bias toward the old notions of New-Darwinism. Consequently, his report and deductions on it are misinformative. Evolution was (and, to a large extent, still is) thought to be based on "variation and survival of the fittest". But in the past the view of the causes of these variations were believed to be basically errors: DNA damage by the environment, and failure of the organism to correct damages or to make precise copies of the DNA. It's been a long time now that this view has changed dramatically, and organisms, even as simple as bacteria, are now known (from before 1990) to possess amazing control over the ways and the contexts in which these variations happen. They can trigger DNA mutation under appropriate conditions (stress, threats to survival), and even control which areas of the genome will be subject to change. This renders organisms much more "smartly" interactive with the environment as might be expected from reading Cziko.

So, what Cziko did not tell about the process of antibody creation by B-Lynphocytes is that when they undergo somatic hypermutation to fine tune their antibody production to the antigen, this hypermutation is, first, triggered by the interaction with the very antigen, and second, it is far from blind: the mutation happens only in a very restricted area of the chromosome, changing only the areas of the antibody molecule that interact with the antigen (and not even the whole molecule!). So this is a very "thematic" kind of mutation-variation; maybe "short-sighted", but surely not "blind"!

When he comments on the phenomenon of "directed mutation", the strange capability of many procarionts (like bacteria) to seemingly direct their mutation to the desired result, he takes a rather cynical and slightly arrogant stand, apparently rejecting the existance of the phenomenon itself, even saying "But let us continue to imagine for a moment that a bacterium was able to change just those genes regulating metabolism in just the right way to allow for the digestion of a foreign sugar". It seems that he read only two research articles on this, and not quite well, and draw much of his attitude towards the phenomenon from his academic-environment prejudiced and uninformed criticism. By the time he was writing his book , directed mutation had been fully demonstrated by many researchers, and not only by Cairns. Actually, even as early as 1984, four years before Cairns revolutionary and controversial paper on it, J.A. Shapiro had already shown the phenomenon fully (Observations on the Formation of Clones Containing araB-lacZ cistrons fusions. Molecular & General Genetics 1984;194(1-2):79-80), only in a much more discreet maner. By 1995, a wealth of information was already available, from researchers like Shapiro and B.G. Hall, among others, and now even eukariotes (yeast) are known to perform "directed mutation" (Hall BG. Adaptive Mutagenesis: a Process that Generates Almost Exclusively Beneficial Mutations. Genetica 1998;102(103):109-125.). Strikingly, this process shows some resemblance to human B-lynphocyte somatic hypermutation!

When Cziko moves on to the other areas, scientific knowledge growth, etc, the already "short-sighted" (and not blind) variation seems to have undergone a surgical operation on its eye and starts to see almost sharply. Also, the second step, that is, the survival of the fittest (in biology, through killing the non-fit) seems to change to a true "selection" process (choosing one among many, by identifying its desirable qualities, which is quite different from "survival of the fittest"). Even Campbell and Pinker, which he defines as fully (or almost) selectionists, seem to turn to rather providential viewpoints, like "innativism" and "constraints", for triggering and orienting the variation, and guiding the selection, not succeding in solving Meno's providential dilema: "...if you don't already possess the knowledge you are looking for, how will you know when you have found it?"

Cziko, like many, wrongly equals "scientific" and "naturalistic" explanations to "mechanical" ones, and since our mechanistic view of nature is basically deterministic, he only sees lamarckism as an instructionist process, not a "freely-willed" one, failing to address vital phenomena like human consciouness and apparent free-will.

Rating: 5 stars
Summary: A brilliant tour de force
Review: We all know about the theory of evolution by natural selection, but what I didn't know was that this idea could be extended to any field in which something new is produced. Cziko brilliantly reviews the application of selection theory (blind variation followed by selection of best fits) to fields as different as neurology, immunology, linguistics, education, pharmacology and artificial intelligence, and presents a strong argument for the claim that innovation in any field can only arise through an application of selection theory. How does our immune system deal with a potentially infinite variety of antigens? Not directly through information contained in the genes, which are quite limited in number. Not through direct copying of the shapes of antigens, since no mechanism allows it to copy an infinite number of potential shapes. Rather, sequential generations of B lymphocytes produce antibodies that fit the antigen better and better, with continual selection of the B lymphocytes that produce the best-fitting antibodies. How do we acquire new knowledge? It is not innate, as Plato claimed. And we don't directly "learn" it from others, except in the sense that a parrot learns. Rather, we are constantly trying to make better and better sense of our perceptions, by building better and better explanations in our minds and rejecting inadequate explanations. Information and instruction received from others are only perceptions to us until we have incorporated them into our own explanatory schemes. So "learning" is actually an active process of explanation-building through trial and error, in other words, a form of blind variation of explanatory schemes and selection of the best ones.

This book is well-written, clear, and immensely "instructive", causing me to modify a number of explanatory schemes in my own mind. I put it alongside the best of Dawkins, Dennett and Wilson. It should have a much wider readership than it apparently has.


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